Strikers Wayne Rooney and Dimitar Berbatov are set to return from hamstring and knee injuries, respectively, but arguably the most important first-team regular back in the fold is central defender Nemanja Vidic.
The Serbian international has been out with the flu for the past week - missing United's 4-0 win at West Ham on Saturday and the 3-1 success at Wolfsburg in the Champions League on Tuesday.
But Ferguson talked up Vidic's chances of being fit for the arrival of Villa at Old Trafford.
'We expect Vidic to be ready for Saturday,' the manager said.
'We'll be ok with that - I'm happy enough if I can play a back four of [Darren] Fletcher, [Michael] Carrick, Vidic and [Patrice] Evra.'
United played a back three against the German side earlier in the week, with midfielders Fletcher and Carrick joining Evra in defence.
However, against Villa, Carrick would partner the returning Vidic in the centre of a four-man back-line with Fletcher on the right flank and Evra in his customary left-back role.
The Serbian international has been out with the flu for the past week - missing United's 4-0 win at West Ham on Saturday and the 3-1 success at Wolfsburg in the Champions League on Tuesday.
But Ferguson talked up Vidic's chances of being fit for the arrival of Villa at Old Trafford.
'We expect Vidic to be ready for Saturday,' the manager said.
'We'll be ok with that - I'm happy enough if I can play a back four of [Darren] Fletcher, [Michael] Carrick, Vidic and [Patrice] Evra.'
United played a back three against the German side earlier in the week, with midfielders Fletcher and Carrick joining Evra in defence.
However, against Villa, Carrick would partner the returning Vidic in the centre of a four-man back-line with Fletcher on the right flank and Evra in his customary left-back role.
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